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Additional info for Nature (Vol. 430, No. 7002, 19 August 2004)
Above all, he was a very kind and considerate person. Born in Northampton and trained at University College London, Crick started graduate work in physics at the beginning of the Second World War. His “unimaginably dull” thesis project was to define the viscosity of water at high pressures. In a career-altering episode during the Battle of Britain in 1940, a bomb fell through the roof of the physics laboratory and exploded on his instrument. Crick then went to work for the Admiralty, designing ‘clever’ mines.
Certain inconsistencies arose in interpreting the interactions between the triplet of bases that defines an amino acid in messenger RNA and the triplet of bases in the transfer RNA molecule. To account for that, in 1966 Crick proposed the ‘wobble’ hypothesis, in which one base of a transfer RNA could adopt two different positions, hydrogen bonding in two different ways. This led to the complete genetic code, relating each amino acid to one or more nucleotide triplets. These monumental discoveries provided the basic framework for understanding the flow of information, and defined the major features of all living systems at the molecular level.
This is in contradiction with the classical ‘thermal bipolar seesaw’ picture, in which southern temperature is determined by northern temperature only20. In addition, southern temperature in case C starts to decrease several centuries before the onset of northern temperature increase. The similarity of southern temperature time series with the freshwater forcing in the North Atlantic is also simulated for different scenarios (not shown) and thus suggests a direct process by which northern freshwater discharge affects southern temperature.
Nature (Vol. 430, No. 7002, 19 August 2004)