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Nature (Vol. 430, No. 6999, 29 July 2004) - download pdf or read online

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Cohen-Fix, O. 27, 492–495 (2002). Lengronne, A. et al. Nature 430, 573–578 (2004). Glynn, E. F. et al. PLoS Biol. 2, e259 (2004). Megee, P. , Guacci, V. & Koshland, D. Mol. Cell 4, 445–450 (1999). 6. Blat, Y. & Kleckner, N. Cell 98, 249–259 (1999). 7. , Cosma, M. , Wirth, K. & Nasmyth, K. Cell 98, 847–858 (1999). 8. Ciosk, R. et al. Mol. Cell 5, 243–254 (2000). 9. Weber, S. A. et al. PLoS Biol. 2, e260 (2004). 10. Bernard, P. & Allshire, R. Trends Cell Biol. 12, 419–424 (2002). 7 highlites 522 NEW MH 26/7/04 2:57 pm Page 522 research highlights Astronomy Light-bending reveals stellar mass Astrophys.

Moreover, the relative positions of the four-helix bundles comprising the second part of D3 and D4 in vinculin differ substantially from those seen in structures of the homologous region of Ȋ-catenin, suggesting that there is significant inter-domain flexibility in this part of the structure1. These structural observations demonstrate that both intra- and interdomain structural changes are associated with activation and ligand binding. What provides the energy needed to remodel and activate vinculin?

It is this process, the emergence of new and better cells, that causes periodic selection, also known as selective sweeps,to prune the inner branches from trees. It seems paradoxical that an apparently successful and competitive set of organisms such as the SAR11 group should also exhibit high diversity in their genomic DNA: one one might expect that keen selection would truncate diversity. This is particularly the case for populations with large effective population sizes, which Kimura10 predicted would be less subject to the process known as genetic drift and therefore more able to ‘fix’ genetic variants that confer a small selective advantage.

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Nature (Vol. 430, No. 6999, 29 July 2004)


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