By Eon Nigel Harris MD, DM, Silvia S. Pierangeli PhD (auth.), Doruk Erkan, Silvia S. Pierangeli (eds.)
The overseas Congress on Antiphospholipid Antibodies is held each 3 years to debate the new advances and destiny instructions in Antiphospholipid Syndrome (APS). This quantity collects the medical highlights and new findings approximately APS that have been generated from the latest thirteenth Congress, held in Galveston, Texas in 2010. Chapters have been written via an internationally-distinguished staff of scientists from the point-of-view of a number of distinctiveness components. every one bankruptcy used to be written in a uniform and systematic foundation to provide the newest evidence-based study, together with the elemental technological know-how of APS, activity strength experiences from the Congress on arguable points of APS, and destiny instructions of APS examine. This e-book will attract all clinicians desirous about the therapy and administration of APS sufferers, to citizens in various clinical subspecialties, and to investigate scientists attracted to a greater realizing of this complicated and evolving ailment.
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Additional resources for Antiphospholipid Syndrome: Insights and Highlights from the 13th International Congress on Antiphospholipid Antibodies
Identified three loci of genetic susceptibility to APS in 89 patients , while Kato et al. showed a higher prevalence of CD36 single-nucleotide polymorphism (SNP) in APS patients, suggesting that 2 What is the Origin of Antiphospholipid Antibodies? 31 scavenger receptor function correlates with resistance to developing APS . Interestingly, two independent groups reported at the same congress that oxidation plays a role as a trigger of the autoimmune response in APS after oxidative modification of immunoglobulins from normal individuals [121, 122].
1963;62:416–30. N. S. Pierangeli 3. Nilsson IM, Asstedt B, Hedner U, et al. Intrauterine death and circulating anticoagulant “antithromboplastin”. Acta Med Scand. 1975;197:153–9. 4. Harris EN. Syndrome of the black swan. Br J Rheumatol. 1987;5:324–6. 5. Harris EN, Gharavi AE, Boey ML, et al. Anticardiolipin antibodies: detection by radioimmunoassay and association with thrombosis in systemic lupus erythematosus. Lancet. 1983;2: 1211–4. 6. Pierangeli SS, Liu X, Barker JH, Anderson G, Harris EN. Induction of thrombosis in a mouse model by IgG, IgM and IgA immunoglobulins from patients with the Antiphospholipid Syndrome.
Mackworth-Young C, Chan J, Harris N, et al. High incidence of anticardiolipin antibodies in relatives of patients with systemic lupus erythematosus. J Rheumatol. 1987;14:723–6. 31. Goldberg SN, Conti-Kelly AM, Greco TP. A family study of anticardiolipin antibodies and associated clinical conditions. Am J Med. 1995;99:473–9. 2 What is the Origin of Antiphospholipid Antibodies? 35 32. Goel N, Ortel TL, Bali D, et al. Familial antiphospholipid antibody syndrome: criteria for disease and evidence for autosomal dominant inheritance.
Antiphospholipid Syndrome: Insights and Highlights from the 13th International Congress on Antiphospholipid Antibodies by Eon Nigel Harris MD, DM, Silvia S. Pierangeli PhD (auth.), Doruk Erkan, Silvia S. Pierangeli (eds.)