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Download e-book for iPad: Advances in Vascular Medicine by Ioannis Papaioannou, James S. Owen (auth.), David Abraham,

By Ioannis Papaioannou, James S. Owen (auth.), David Abraham, Handler Clive, Michael Dashwood, Gerry Coghlan (eds.)

ISBN-10: 1848826362

ISBN-13: 9781848826366

Understanding the numerous complicated mobile and molecular mechanisms underlying human vascular illnesses is key in enhancing the administration of sufferers with this clinically vital and wide-ranging workforce of illnesses. this can be quite very important while contemplating the level of this factor around the world.

Written through a group of world-renowned gurus, Advances in Vascular Medicine highlights many of the relationships among simple technology and scientific medication, and reports either learn and scientific perform tools and results in vascular biology and pathobiology. it truly is an authoritative reference for those vital themes of vascular biology and comprises chapters that designate the medical matters to the fundamental scientist in addition to supplying clinicians with a systematic grounding in vascular ailments. even though there's nonetheless a lot paintings to be performed to strengthen knowing of vascular affliction, the data and insights contained during this e-book are an important contribution to the literature, giving scientists and clinicians the chance to profit extra approximately this fascinating box of biomedicine.

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The goal for future studies is to release the enormous potential of targeted gene editing for therapeutic gain. One approach in advanced development exploits the observations that double-stranded breaks (DSBs) in genomic DNA are repaired extremely efficiently by the cell’s HR machinery and that the template used can be extra-chromosomal DNA. In practice, the DSB is specifically introduced into the target gene using a custom engineered zinc-finger nuclease in the presence of an exogenously delivered homologous DNA template harboring the desired sequence change(s).

Implications of cell cycle progression on functional sequence correction by short single-stranded DNA oligonucleotides. Gene Ther. 2005;12:546–551. 51. Disterer P, Simons JP, Owen JS. Validation of oligonucleotide-mediated gene editing. Gene Ther. 2009;16:824–826. 52. Papaioannou I, Disterer P, Owen JS. Use of internally nuclease-protected single-strand DNA oligonucleotides and silencing the mismatch repair protein, MSH2, enhance replication of corrected cells following gene editing. J Gene Med.

Zimmermann TS, Lee AC, Akinc A, et al. RNAi-mediated gene silencing in non-human primates. Nature. 2006;441:111–114. 35. Frank-Kamenetsky M, Grefhorst A, Anderson NN, et al. Therapeutic RNAi targeting PCSK9 acutely lowers plasma cholesterol in rodents and LDL cholesterol in nonhuman primates. Proc Natl Acad Sci U S A. 2008;105:11915–11920. 36. Cartegni L, Chew SL, Krainer AR. Listening to silence and understanding nonsense: exonic mutations that affect splicing. Nat Rev Genet. 2002;3:285–298. 37.

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Advances in Vascular Medicine by Ioannis Papaioannou, James S. Owen (auth.), David Abraham, Handler Clive, Michael Dashwood, Gerry Coghlan (eds.)

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