By Frank J. (Editor) Dixon
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Extra info for Advances in Immunology, Vol. 46
Anderson, M. L. M . , Szajnert, M. ,Kaplan, J. , McColl, L . , and Young, B. D. (1984). Nucleic Acids Res. 12, 6647. 48 ERIC LA1 ET AL. Anderson, M. L. , Kellow, J. , and Young, B. D. (1985). Nucleic Acids Res. 13, 2931. , Peterson, P. , and Rask, L. J. Biol. Chem. 262, 8748. Appella, E. (1971). Proc. Natl. Acad. Sci. A. 68, 590. , and Ein, D. (1967). Proc. Natl. Acad. Sci. A. 57, 1449. , and Hood, L. (1985). Nature (London) 316, 783. , and Strominger, J. L. (1986). Adu. Hum. Genet. 15, 197. , Lillie, J.
1981). In 1982, Shimizu et al. reported the complete linkage of the constant region gene segments. 5-kbCs-55-kb-C,3-34-kb-C,1-21-kb-C,2b-15-kb-C,2a-l4-kb-C~-l2-kb-C, (Fig. 5a). , 1981). The 5 ’ -most & gene segment belongs to the two-member v~FL16subfamily. The other member of the h F L l 6 subfamily was found to be interspersed with the k S P 2 subfamily. All of the gene segments in the constant region are in the same transcriptional orientation, and the TABLE I1 VH SUB FA MI LIE^ Subfamily 3609(V31) J558 J606 VGAM3-8 907 3660 X24 Q52 7183 VHlO Kabat et al.
Physical map of the mouse H-2 Major Histocompatibility Complex. The orientations of the genes are shown as arrows above the genes. The distance between S and D has not been determined. 30 ERIC LA1 ET A L . , 1987b). The transcriptional orientation of the S region genes are the same as the K region genes, but opposite to that of the D region. Muller et ul. (1987a) have found that tumor necrosis factor (TNF-a) and lymphotoxin (TNF-P) are located within the H-2 complex and map close to the D region (see Fig.
Advances in Immunology, Vol. 46 by Frank J. (Editor) Dixon