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Masayasu Hiraoka, International Congress on Electrocardiol's Advances in Electrocardiology 2004: Proceedings of the 31th PDF

By Masayasu Hiraoka, International Congress on Electrocardiol

ISBN-10: 9812561072

ISBN-13: 9789812561077

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Additional resources for Advances in Electrocardiology 2004: Proceedings of the 31th International Congress on Electrocardiology (Advances in Electrocardiography)

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G. Lopes and J. C. Cunha Autonomic Dysfunction in Children with Chronic Renal Failure W. Bobkowski, A. Nowak, J. Zuchwieja, B. Mrozinski and A. Siwinska 17 Modeling of Cardiac Electrical Activity 796 80 1 805 Reflections on T Waves A. van Oosterom 807 Electrocardiographic Imaging (ECGI): Validation and Application in Humans Y. Rudy 816 Whole Heart Model and ECG/MCG Inverse Problem Y. Okamoto 817 Changes in Rabbit Heart Vulnerability during Phase 1A of Acute Global Ischemia 818 N. Trayanova and B.

We discussed plans to submit a grant to the National Institutes of Health for funding; as we both were already recipients of NIH funds, the possibility of a cooperative international grant was not unrealistic. When Arthur Moss asked how long should we run this international registry I replied “for 25 years”, an unmistakable sign that we were very young. It took two years until the International LQTS Registry started up in 1979 (15,16), and now 25 years later the Registry is still active and thriving with enrolment of over 1200 LQTS families and continuous National Institutes of Health fimding for the past 20 years.

The first publication of findings from the Registry occurred in 1985 when we highlighted the risk factors for cardiac events in 196 LQTS patients (17). By 1991, we expanded the prospective study of the clinical course of this disorder to 1,016 affected individuals in 328 LQTS families (18). The diagnostic criteria for LQTS have been established (19). Important findings from the Registry during the past decade have included: age and sex-related differences in the clinical manifestations of LQTS (20); influence of pregnancy on the risk for cardiac events in LQTS (21); ECG T-wave patterns in genetically distinct forms of LQTS (22); clinical course of LQTS by genotype (23,24); the spectrum of mutations in LQTS genes (25); increased risk associated with mutations in the pore region of the hERG gene (26); role played by physical exercise, emotions, arousal, and redsleep as triggers and facilitators for syncope and sudden cardiac death in LQT1, LQT2, and LQT3 (27); effectiveness of beta-blocker therapy, particularly according to genotype (28,29); potential gene-specific usefulness of sodium channel blockers (mexiletine and flecainide) in the treatment of patients with the LQT3 mutations (30,31); and left cardiac sympathetic denervation in the management of high-risk LQTS patients (32).

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Advances in Electrocardiology 2004: Proceedings of the 31th International Congress on Electrocardiology (Advances in Electrocardiography) by Masayasu Hiraoka, International Congress on Electrocardiol

by Charles

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